Metabolic Therapy

From his well-equipped clinic in Grand Cayman, Dr. Kwinter collaborates with leading medical specialists around the world to deliver highly personalized treatments for various conditions. This includes the Press Pulse Protocol, a pioneering complementary approach to cancer care.

Press Pulse Protocol

Dr. Thomas Seyfried is an American professor of biology, genetics, and biochemistry at Boston College. He is a proponent of a theory of cancer pathogenesis that regards damage to cellular respiration as the initial defect that subsequently leads to the genetic mutations seen in cancers. This view of the metabolic origins of cancer brings to light the ability to selectively starve cancer cells of their required biochemical fuels (glucose and glutamine) using the novel "Press Pulse" approach.

Foreword in Starving Cancer Cells: Evidence-Based Strategies to Slow Cancer Progression, 2021

Ketogenic metabolic therapy, using calorie-restricted high fat, low carbohydrate ketogenic diets, is a therapeutic strategy that can be effective for starving cancer cells. This approach shifts the body away from using glucose to using ketone bodies and fats for energy, thus starving cancer cells of their prime fermentable fuel. The dependency of tumor cells on glucose has become known as the Warburg effect, in recognition of Otto Warburg who first described cancer as a disease of mitochondrial energy metabolism. As ketone bodies and fats are nonfermentable, these fuels are accessible only to normal cells, which contain normal mitochondrial function. We found that ketogenic metabolic therapy used with drugs that also target glutamine can be effective in managing advanced-stage brain cancer. The key is to simultaneously restrict availability of both glucose and glutamine. As most if not all cancers depend on glucose and glutamine fermentation for survival, this therapeutic starvation strategy should be effective in managing most if not all cancers.

Learn more:

YouTube video [1:05:28]
Dr. Seyfried joins a roundtable discussion where patients share their experiences utilizing metabolic therapy in combination with standard of care.

YouTube video [42:07]
Dr. Seyfried is interviewed by Dr. Sanjay Juneja, a Hematologist and Medical Oncologist at Baton Rouge General Hospital.

A documentary film series that relates advances in cancer research from the 1920s to the present as told by the original researchers, their biographers and contemporaries.

PDF [976KB]
Seyfried TN, Yu G, Maroon JC, D'Agostino DP. Press-pulse: a novel therapeutic strategy for the metabolic management of cancer. Nutr Metab (Lond). 2017 Feb 23;14:19. doi: 10.1186/s12986-017-0178-2. PMID: 28250801; PMCID: PMC5324220.

PDF [1.7MB]
Seyfried TN. Cancer as a mitochondrial metabolic disease. Front Cell Dev Biol. 2015 Jul 7;3:43. doi: 10.3389/fcell.2015.00043. PMID: 26217661; PMCID: PMC4493566.

YouTube video [54:40]
Dr. Seyfried describes cancer as a metabolic disease with metabolic solutions.

PDF [2.3MB]
Seyfried TN, Flores RE, Poff AM, D'Agostino DP. Cancer as a metabolic disease: implications for novel therapeutics. Carcinogenesis. 2014 Mar;35(3):515-27. doi: 10.1093/carcin/bgt480. Epub 2013 Dec 16. PMID: 24343361; PMCID: PMC3941741.

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